在机械研磨(MM400)无溶剂条件下,用连二亚硫酸钠(保险粉)在1h内可以将各种芳香硝基化合物以中等到近定量的产率(79%~95%)还原成相应的胺。该转化在室温下以较高的化学选择性高效完成,反应的后处理及分离纯化操作简单。所有产物通过熔点、红外及核磁共振氢谱进行了表征。
Under mechanochemical milling(MM400) and solvent-free conditions,reduction of aromatic nitro compounds with sodium hydrosulfite can be accomplished efficiently within 1 h,affording the corresponding amines in moderate to almost quantitative yield(79%~95%).This transformation was accomplished at room temperature with very high efficiency and chemoselectivity,thus the work-up and purification procedure were very simple.All the products were characterized with mp,IR and 1H NMR.