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中文摘要：
磷脂酰肌醇-3-激酶／蛋白激酶B／雷帕霉素靶蛋白（P13K／Akt/mTOR）信号通路介导许多在肿瘤和自身免疫病发生中至关重要的细胞生物学过程，对于细胞增殖、细胞活化、血管生成起到重要作用。P13K／Akt／mTOR信号通路作为药物治疗靶点进行抗细胞增殖活化的研究近年来发展迅速。本文从P13K／Akt／mTOR信号通路的上下游、信号通路抑制剂以及与信号通路相关的自身免疫病等方面作一综述。
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