热激蛋白70(HSP70,heat shock protein 70)广泛参与胁迫环境的响应,在诱发人体肿瘤细胞凋亡,增强肿瘤的免疫原性中起着重要作用。然而,植物HSP70的生理功能研究起步较晚,最近的研究发现植物HSP70在细胞内主要参与新生肽的折叠与成熟、损伤蛋白的降解和蛋白运输;植物HSP70在非生物胁迫环境的应答、抗病性及植物发育中起着重要作用。本文从分子生物学角度,系统综述了植物HSP70分子作用机理研究的进展,以及在提高植物抗逆性方面的作用,以期为基因工程方法改良作物抗性提供参考。
Heat shock protein 70 (HSP70) widely responded to stress environment and played an important role in the promoting tumor cell apoptosis and the control of normal mitosis growth of human cells. However,the physiological function research of HSP70 started later in plant than in animal. Recent researches revealed that plant HSP70 was primarily involved in folding and maturation of nascent peptides, protein transporting, and the degrada- tion of damage protein. Plant HSP70 played an important role in environmental stress response,disease resistance, and development. This paper discussed the molecular functions of HSP70 in enhancing the plant stress tolerance, and systematically reviewed latest progresses on molecular mechanism of plant HSP70 as well as improvement of plant resistance to facilitate broaden work.