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真核细胞起始因子-4E表达与非小细胞肺癌预后的相关性

ISSN号：1673-7210
期刊名称：《中国医药导报》
时间：0
分类：R734[医药卫生—肿瘤;医药卫生—临床医学]
作者机构：[1]温州医科大学附属黄岩医院浙江省台州市第一人民医院呼吸内科,浙江台州318020
相关基金：浙江省台州市黄岩区科技局基金资助项目（编号2012038）。

关键词： eIF-4E基因, 表达, 非小细胞肺癌, 预后, eIF-4E gene, Expression, NSCLC, Prognosis

中文摘要：

目的：探讨真核细胞起始因子-4E（eIF-4E）在非小细胞肺癌（NSCLC）组织中的表达情况及其与预后的关系。方法选择2009年1月～2010年12月温州医科大学附属黄岩医院外科手术切除的NSCLC组织60例以及30例癌旁正常组织样本作为对照，采用免疫组化法检测NSCLC组织以及癌旁正常肺组织中elF4E的表达。NSCLC患者术后均接受2周以上的榄香烯联合顺铂化疗，对所有患者均进行系统地随访评价，分析eIF-4E的表达与无瘤生存期（DFS）和总生存时间（OS）的关系。结果 eIF-4E在NSCLC癌组织中的表达率为80.00%，显著高于正常癌旁组织（33.33%），差异有高度统计学意义（P〈0.01）。年龄≥60岁及TNM分期为Ⅲ~Ⅳ期患者的eIF-4E高表达率明显高于年龄〈60岁及分期为I~Ⅱ期的患者，差异均有统计学意义（P〈0.05）。 eIF-4E低表达患者的DFS和OS均显著高于高表达者，差异有统计学意义（P〈0.05）。结论 eIF-4E基因在NSCLC组织中呈高水平表达，榄香烯联合顺铂化疗后eIF-4E低表达患者的DFS和OS明显延长。 eIF-4E高表达水平可作为NSCLC不良预后的预测因子。

英文摘要：

Objective To investigate eIF-4E expression in patients with non-small cell lung cancer （NSCLC）, and its correlation with prognosis. Methods Tumor tissues were collected from 60 NSCLC patients who underwent surgical re-section from January 2009 to December 2010 in the Affiliated Huangyan Hospital of Wenzhou Medical University, and 30 adjacent normal tissues samples were also collected. The expression level of eIF-4E in NSCLC tissues and adjacent normal tissues were measured by immunohistochemical method. All the NSCLC patients after resection were subject to treatment with elemene plus cisplatin for more than 2 weeks. A systematic follow-up evaluation was also performed to investigate the correlation of eIF-4E expression level with disease-free survival （DFS） and overall survival （OS）. Re-sults The expression rate of eIF-4E in the tumor tissues （80.00%） was significantly higher than that in adjacent normal tissues （33.33%）, the difference was statistically significant （P〈 0.01）. The eIF-4E high expression rate of the patient with age≥60 years and clinical stage of Ⅲ-Ⅳ was higher than whose age〈60 years and clinical stage ofⅠ-II, the differences were statistically significant （P 〈 0.05）. The DFS and OS values of patients with low eIF-4E expression level were significantly larger than those of patients with high eIF-4E expression level, the differences were statistically significant （P〈 0.05）. Conclusion eIF-4E is highly expressed in NSCLC tissues; the DFS and OS values of patients with low eIF-4E expression level are significantly larger. High eIF-4E expression level may be an independent predic-tor of poor NSCLC prognosis.

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