中文摘要：

内分泌干扰物（endocrine disruptive chemicals，EDCs）可通过干扰雌激素受体（ER）信号通路影响相关转录活动．在阐述ERa和p两个亚型的基本结构特征和其信号转导途径的基础上，重点回顾近年来关于EDCs对ER信号转导通路干扰机制的研究进展．EDCs对ER信号通路的干扰机制包括配体依赖和非依赖两种，配体依赖机制分为直接作用和间接作用．直接作用的机制是EDCs可作为配体与雌激素竞争ER上的结合位点，从而影响ER的促转录活性．间接作用机制的研究热点集中在芳香烃受体（aryl hydrocarbon receptor，AhR），EDCs作为配体可激活AhR，而AhR能够促进ER蛋白泛素化并降解，也可通过与ER竞争辅助激活因子或直接影响ER介导的DNA转录．EDCs通过非配体依赖以及非基因组途径干扰机体的内分泌活动的机制目前仍不清楚，提示未来需注重研究EDCs对多种信号通路的影响．

英文摘要：

The endocrine disrupting chemicals （EDCs） can affect transcriptional activities via influencing estrogen receptors （ER） signaling pathway. This review focus on the mechanism about effect of EDCs on ERs signal pathway. The characteristic and signal pathway of the two estrogen receptors （ERs）, ERa and ER~, were firstly expatiated. The effect of EDCs on ER signaling pathways are consist of the ligand-dependent and non-ligand-dependent pathway, and the ligand-dependent pathways include the modes of direct and indirect action. The direct action of EDCs can change the transcriptional activity of ER through the competive binding between EDCs as ligand and estragen to the same site. The indirect action is mainly regarded that the aryl hydrocarbon receptor （AhR） can be activated by EDCs as ligand, then AhR makes ERs being ubiquitinated and degradated, or competitive binding the co-activator with ER or direct disrupting the DNA transcription. The mechanisms of EDCs disrupting the internal secretion involving non- ligand-dependent and non- gene pathway are not clear. This review prompted that the research on EDCs＇s effect should be paid more attention to exploring the mechanism about multi signals pathways in future.