中文摘要：

目的了解高氟区改水后不同程度氟骨症患者的肺功能的损害。方法选新疆氟病区轻、中、重不同病情的氟骨症患者65例和非病区正常对照组23名，对所有调查对象的肺功能进行检测。结果病例组MMEF％、MEF75％、MEF25％、FEV1／FVC等指标与对照组相比均有不同程度降低，且有统计学差异（P〈0．05）；对各组进行两两比较，轻度和重度组MMEF％、MEF50％有统计学差异（P〈0．05），重度组的FEV1／FVC低于其他3组且有统计学差异（P〈0．05），重度组和中度组的MEF75％低于轻度组且差异有统计学意义（P〈0．05）。结论氟骨症患者的肺功能在改水降氟18年后仍然出现一定程度的损伤，其程度随氟骨症病情的加重而加重。建议可将MMEF％、MEF75％、MEF25％、FEV1／FVC等指标列为氟骨症患者肺功能监测的首选指标。

英文摘要：

Objective In order to investigate the pulmonary function damage of drinking - skeletal fluorosis patients after water improvement. Methods 65 cases of the patients with different degree skeletal fluorosis from endemic fluorosis region in Xinjiang,and 23 residents without skeletal fluorosis as control from no endemic fluorosis region were determined pulmonary function. Results Pulmonary function investigation showed that MMEF% , MEF75%, MEF25% , FEV1/FVC were significantly lower in patients than the control（ P 〈0.05）. MMEF% ,MEF50% were significant lower in the severe group than the mild group （ P 〈0.05）. FEV1/FVC of the severe group were significantly lower than the other groups （ P 〈0.05）. MEF75% of the severe and moderate group were significantly lower than those of mild group （ P 〈 0. 05 ）. Conclusions High level of fluoride in drinking water can cause pulmonary function damage on skeletal fluorosis patients even after water improvement for 18 years . There is relationship between pulmonary function damage and the degree of skeletal fluorosis. We can use MMEF% ,MEF75% , MEF25% ,FEV1/FVC as sensitive pulmonary function index to monitor the development of skeletal fluorosis.