中文摘要：

酰氨质子转移（amide proton trans{er，APT）成像是一种新的分子MRI技术，它可用来测量组织中内源性蛋白质．理论上，APT-MRI信号强度主要取决于游离蛋白质的酰氨质子浓度以及交换速度，而酰氨质子交换速度与组织pH有关．因此，APT-MRI技术已经被用于无创性中风pH成像（通常pH降低）和肿瘤蛋白质含量成像（通常蛋白质量提高）．近期对大鼠的实验表明，APT—MRI技术可用来区分放射性坏死和胶质瘤．该综述文章简要地介绍了APT成像的基本原理以及它在动物模型与临床中风和肿瘤成像中的应用．

英文摘要：

Amide proton transfer （APT） imaging is a novel molecular MRI technique that generates image contrast based on endogenous cellular proteins in tissue. Theoretically, the APT- MRI signal depends primarily on the mobile amide proton concentration and amide proton exchange rates （which are related to tissue pH）. The APT technique has been used for non-invasive pH imaging in stroke （where pH drops） and protein content imaging in tumor （where many proteins are overexpressed）. It has been demonstrated recently in animal models that the APT- MRI signal is also a unique imaging biomarker to distinguish between radiation necrosis and active tumor. In this paper, we will briefly introduce the basic principles of APT imaging and review its applications in stroke and brain tumor studies in animal models and patients.