中文摘要：

自噬的主要作用是收集并降解细胞浆内的无用的细胞器及大分子物质，用于细胞结构的重建和修复，及在饥饿时给机体提供营养来源。研究发现自噬功能会随着年龄增长而衰退。这种衰退可能是由于不限制饮食而发生年龄相关的细胞结构改变及功能下降所致。热限制及拮抗胰岛素类信号可以上调自噬。同时发现，终生给予抗脂质分解类药物可以降低葡萄糖和胰岛素的水平，诱导自噬并加强抗老化效应。

英文摘要：

Macroautophagy is a process that sequesters and degrades organelles and macromolecular constituents of cytoplasm for cellular restructuring and repair, working as a source of nutrients for metabolic use in early starvation. Extensive evidence has been reported that maeroautophagy process declines with the increasing age. This impairment, probably due to unrestricted feeding, may cause accumulation of altered structures leading to the age-related decline in cell functions. It has been suggested that caloric restriction （CR） and disruption of insulin-like signals contrast the process of aging by prolonged stimulation of macroautophagy. According to this hypothesis, it is shown that life-long weekly administration of an anti-lipolytic drug could decrease the glucose and insulin levels and stimulate autophagy and intensifies anti-aging effects.