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中文摘要：
目的：通过与慢性束缚应激造模法比较，探讨居住入侵法制备经前期综合征（PMS）肝气郁证大鼠模型的可行性。方法：以慢性束缚应激造模法为对照，将国外应用较为成熟的居住入侵法用于制备PMS肝气郁证大鼠造模，并用旷场实验、悬尾实验等行为学方法系统评价造模效果，比较两种造模方法的优劣。结果：两种方法制备的PMS肝气郁证模型大鼠旷场实验水平得分、垂直得分及总分均无显著性差异（P〉O．05）。结论：采用居住入侵法制备PMS肝气郁证大鼠模型能有效模拟人类由于情质异常引发的经前抑郁及经后抑郁症状消失状态，且克服了慢性束缚应激法躯体刺激明显的缺点，但其造模成功率低，模型稳定性方面也有待进一步考察。
英文摘要：
This study was aimed to investigate the feasibility of establishing premenstrual syndrome （PMS） liver-q/ depression rat model with resident-intruder paradigm compared to chronic restraint stress. PMS liver-q/ depres- sion rat model was prepared with chronic restraint stress and resident-intruder paradigm, respectively. The effect was systematically evaluated through behavioral methods such as open-field test and tail suspension test. Then, results from both groups were compared. The results showed that both chronic restraint stress and resident-intrud- er paradigm can effectively simulate the state of premenstrual depression and postmenstrual disappearance. The re- sults of open-field test suggested that there was no significant difference between these two methods （P 〉 0.05）. It was concluded that as a social psychological the process of clinical PMS liver-q/ depression obvious body stress of chronic restraint stress was needed to examine its stability. stress method, resident-intruder paradigm can preferably simulate caused by emotion abnormality, and overcome the disadvantage of method. But the success ratio was too low, and further inspection was needed to examine its stability.
同期刊论文项目
同项目期刊论文
Metabolic and Behavioral Patterns in a Pre-Menstrual Syndrome Animal Model with Liver-qi Invasion an
Prevalence of premenstrual syndrome and premenstrual dysphoric disorder in a population-based sample
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