中文摘要：

造影剂肾病（contrast-induced nephropathy,CIN）为血管内应用造影剂后出现的一过性肾功能异常。虽然CIN为自限性疾病,但仍可能导致慢性肾功能不全,尤其合并多种危险因素的情况下。目前认为CIN的病理生理机制主要涉及血流动力学改变,氧化应激及细胞毒性。作为医源性急性肾功能不全的主要原因之一,目前未有特异性治疗措施,以预防为主。本文将重点讨论CIN合并慢性肾脏病的研究进展,尤其讨论其危险因素、发病机制及预防措施。

英文摘要：

Contrast-induced nephropathy（CIN） is defined as a transient decline in kidney function following the intravascular administration of contrast media.Though CIN is a disease of self-limited,it has also induced chronic renal insufficiency,especially for patients with many risk factors.Now,we have considered that pathophysiology of CIN is related to hemodynamic changes,oxidative stress and cytotoxicity.As one of mainly causes of hospital-acquired acute renal failure,there are no special therapeutic measures for CIN,but prevention.In the review,we forced on the researches of CIN with chronic kidney disease,especially the risk factor,pathogenesis and prevention strategies.