中文摘要：

椎间盘退行性变疾病是一类具有高发病率及高致残率的疾病，是临床上引起腰背痛致使工作能力丧失的最主要病因。建立经济、可靠、重复性好的椎间盘退变动物模型，是实验研究椎间盘退变病理生理学变化的首要前提。因此，综合分析和评价近年来常用的实验兔椎间盘退变模型构建方法，对制备椎间盘退行性变模型在实践上具有参考意义。

英文摘要：

Intervertebral disc degeneration （IDD） is a disease with high incidence and mutilation rates, and the main etiologic factor of low back pain in clinic and loss of ability to work. To establish an economic, reliable, and reproducible intervertebral rabbit interve animal model is a primary premise for studying disc degeneration. In this review rtebral disc degeneration model in we compare and recent years the pathological and physiological changes of evaluate five common methods for establishing