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可注射型纳米羟基磷灰石/壳聚糖复合材料骨水泥的研究
  • ISSN号：1000-6737
  • 期刊名称：《生物物理学报》
  • 时间：0
  • 分类：TB321[一般工业技术—材料科学与工程]
  • 作者机构：[1]北京航空航天大学生物与医学工程学院,教育部生物力学和力生物学重点实验室,北京100191, [2]北京农业职业学院国际教育学院,北京100012
  • 相关基金：国家自然科学基金项目（10925208 50803032 10802006）; 北京航空航天大学SRTP科研项目
作者： 於娟[1], 周钢[1], 杨欣[2], 袁伟伟[1], 宋崴[1]
关键词： 纳米羟基磷灰石/壳聚糖复合材料, 骨水泥, 抗压强度, n-HA/CS composite, Bone cement, Compressive strength
中文摘要：

为制备可满足临床需要的可注射磷酸钙骨水泥,以自制纳米羟基磷灰石/壳聚糖复合材料作为骨水泥的固相粉体,将柠檬酸、醋酸等按一定比例配置成溶液作为液相,设计正交试验以简化实验,从凝固时间和抗压强度两方面来确定该骨水泥体系的最佳配比。再通过转靶X射线衍射仪、傅立叶变换红外光谱仪、扫描电子显微镜手段分析了各个组分对凝固时间和抗压强度的影响。此外,还通过细胞培养实验评价了最优条件下骨水泥的生物相容性。

英文摘要：

In this paper,self-made nano-hydroxyaptite/chitosan（n-HA/CS） composite was used for solid phase of bone cement.While the liquid phase was citric acid and acetate acid according to a certain percentage.The design orthogonal was tested to determine the best ratio of the system from the coagulation time and compressive strength of the bone cement.And XRD,IR and SEM were used to analyze this new system after coagulation.In addition,the cell culture was used to evaluate biocompatibility.Thus this synthesis injected bone cement was potentially prepared injectable bone cement to meet the clinical needs.

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期刊信息
  • 《生物物理学报》
  • 北大核心期刊（2011版）
  • 主管单位:中国科协
  • 主办单位:中国生物物理学会
  • 主编：沈恂
  • 地址：北京朝阳区大屯路15号生物物理研究所内
  • 邮编：100101
  • 邮箱：acta@sun5.ibp.ac.cn
  • 电话：010-64888458
  • 国际标准刊号：ISSN：1000-6737
  • 国内统一刊号：ISSN：11-1992/Q
  • 邮发代号:
  • 获奖情况:
  • 二次获得中国科协优秀科技期刊奖
  • 国内外数据库收录:
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  • 被引量:7189