中文摘要：

miRNAs 是一个班小， 22nt，否定地在 post-transcriptional 调整基因表示的非编码的 RNA 铺平。他们在操作在各种各样的优核质涉及房间开发，增长和 apoptosis 的基因表示起深刻、弥漫的作用，在理论，它能在理论提供存取给许多人的疾病。最近的证据证明那个异常 miRNA 表达式是肿瘤开发的一个特点，表明 miRNA 基因能作为在人的身体的潜在的 oncogenes 和抑压者工作。主要由打断房间的 miRNAs 罐头 affect 肿瘤发生在细胞的水平并且由与发信号交往骑车， oncogenes 并且与对在分子的水平的环境因素的反应。确定的 miRNA 表示签名能是一个有势力工具以后诊断并且对待人的癌症。

英文摘要：

miRNAs are a class of small, ∽22nt, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. They play profound and pervasive roles in manipulating gene expression involved in cell development, proliferation and apoptosis in various eukaryotes, which, in theory, could provide an access to many human diseases in theory. Recent evidence demonstrates that aberrant miRNA expression is a hallmark of tumor development, revealing that miRNA genes could function as potential oncogenes and repressors in the human body. miRNAs can affect tumorigenesis mainly by interrupting the cell cycle at the cellular level and by interacting with signaling, oncogenes and with the response to environmental factors at the molecular level. The established miRNA expression signature could be a potent tool to diagnose and treat human cancers in the future.