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天然冰片对大鼠细胞色素P450四种亚型活性的影响
  • ISSN号:1009-2501
  • 期刊名称:中国临床药理学与治疗学
  • 时间:2013.3
  • 页码:121-127
  • 分类:R284.1[医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]广州中医药大学中药学院,广州510006, [2]中山大学药学院,广州510006
  • 相关基金:国家自然科学基金项目(81173564);国家自然科学基金项目(81274028)
  • 相关项目:基于"脑微透析-药动学/药效学"的交泰丸"配伍生新"机制研究
中文摘要:

目的:研究5种紫珠属药材中总酚、总黄酮与其抗氧化活性的相关性.方法:采用紫外分光光度法测定5种紫珠属药材总酚和总黄酮的含量;采用清除O2-·,DPPH·,ABTS+·,·OH评价法、Cu2+螫合法、Fe3+还原法及对大豆卵磷脂脂质过氧化的抑制效果评价它们之间抗氧化活性的差异.结果:5种药材的总酚和总黄酮含量相差较大,其中,裸花紫珠含量最大;各种方法所得抗氧化活性强弱顺序有区别;除了抗脂质过氧化外,其他方法所得结果均与总酚和总黄酮含量呈正相关.结论:5种紫珠属药材富含总酚和总黄酮成分,具有较强抗氧化活性,可以作为天然抗氧化剂进行开发.

英文摘要:

Objective:To study the Correlation of the contents of total phenols and total flavonoids and antioxidant activities of five Callicarpa species.Method:The contents of total phenols,total flavonoids of five Callicarpa species were detected with Uv-Visible spectrophotometer.Subsequently,the antioxidant activities of five Callicarpa species were determined by seven antioxidant methods,including ·O2-scavenging,DPPH ·scavenging,ABTS +·scavenging,·OH scavenging,Cu2 +-chelating,and Fe3 + reducing assays,anti-lipidperoxidation.Result:The contents of total phenols,total flavonoids of five Callicarpa species were significantly different with each other and Callicarpa nudiflora Hook.et Arn possessed the highest contents.There were various kinds of relationship about antioxidant activities of five Callicarpa species from seven methods.The results of correlation analysis indicated that there was a positive correlation between the contents of total phenols and total flavonoids and antioxidant activities apart from anti-lipidperoxidation activity.Conclusion:Five Callicarpa species were rich in phenols and flavonoids,had excellent antioxidant activities,so they would be developed as new natural antioxidants.

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期刊信息
  • 《中国临床药理学与治疗学》
  • 主管单位:中国科学技术协会
  • 主办单位:中国药理学会
  • 主编:孙瑞元
  • 地址:安徽芜湖市皖南医学院弋矶山医院
  • 邮编:241001
  • 邮箱:cjcpt96@163.com
  • 电话:0553-5738350 5739333
  • 国际标准刊号:ISSN:1009-2501
  • 国内统一刊号:ISSN:34-1206/R
  • 邮发代号:26-165
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),波兰哥白尼索引
  • 被引量:17630