中文摘要：

转移是恶性肿瘤的重要生物学特征之一,与肿瘤患者的预后紧密相关。近年来研究表明,去整合素-金属蛋白酶8（a disintegrin and metalloprotease 8,ADAM8）在多种恶性肿瘤中呈现高表达状态,且在恶性肿瘤的转移中发挥着重要的作用。研究显示,ADAM8过表达可减弱肿瘤细胞间的黏附作用,并促进细胞外基质（extracellular matrix,ECM）降解和细胞膜上细胞因子释放,同时有助于肿瘤部位新生血管生成,从而促进了肿瘤细胞转移。因此,抑制ADAM8有可能对肿瘤转移产生抑制作用,这使得ADAM8成为恶性肿瘤的预后指标和潜在治疗靶点,备受关注。该文对ADAM8与肿瘤转移的研究进展进行综述,探讨ADAM8介导的肿瘤转移的机制和靶向ADAM8进行肿瘤转移治疗的策略,为后续研究和临床治疗提供重要的参考。

英文摘要：

Tumor metastasis is one of the important biological characteristics of malignant tumor,which is closely related with the prognosis of the cancer patients. High expression of ADAM8 in varieties of tumors was revealed in many recent studies,and such aberrant expression played a crucial role in regulating of tumor metastasis. Studies showed that overexpression of ADAM8 attenuated the intercellular adhesion effect,promoted tumor angiogenesis,and enhanced the degradation of ECM as well as the releasing of cytokines. Therefore,suppression of ADAM8 may lead to inhibition of tumor metastasis,which makes ADAM8 a particular attractive target as it can be used as a prognostic indicator and a potential therapeutic target of malignant tumor. A review about the relations between ADAM8 protein＇s abnormal expression and tumor occurrence was discussed in this paper,also include discussion about the mechanisms of ADAM8 protein＇ s disorder-induced tumor formation,as well as therapeutic strategies based on ADAM8-targeted,which may provide references for follow-up research and clinical treatment.