中文摘要：

头颈部鳞状细胞癌是一种临床常见的恶性病损,患者常出现多处原发肿瘤以及原发肿瘤完全切除后肿瘤的复发.区域癌化理论认为,由于整个区域组织的多基因异常改变导致整个上呼吸道和上消化道的上皮表层具有增高的发生恶性病损或癌前病损的危险性,而组织细胞内基因的异常改变则是由于组织长期暴露于致癌因素下的结果.该理论可以解释上呼吸道和消化道黏膜易受癌前病损影响,该区域原发肿瘤易频繁复发等临床现象,此理论为更好地阐明头颈部鳞状细胞癌的发生过程提供了思路.本文对区域癌化的概念和临床应用进行综述.

英文摘要：

Head and neck squamous cell carcinoma（HNSCC） is among the most common malignances worldwide.Patients with HNSCC often develop primary tumors at multiple sites and have tendency for local recurrences following curative resectional surgery.Field cancerization theory presumes that,after repeated carcinogenic exposures,the entire superficialepitheliium of the upper aerodigestive tract has an increased risk for developing （pre）malignant lesions because of multiple genetic abnormalities.This theorywell explains the strong potential with malignant transformation and loco-regional recurrence in HNSCC,and helps to better understand the pathogenesis,and thus provides a new idea for prevention and treatment of this disease.This paper will give an overview of field cancerization,including the concept and its clinical application.