中文摘要：

这研究试图在中国在食道的有鳞的房间癌(ESCC ) 的风险在 X 光检查修理跨 complementing group-1 基因(XRCC1 ) 并且生活方式因素和他们的可能的相互作用探索三普通单个核苷酸多型性的角色的目的。432 个盒子和 915 控制的基于人口的盒子控制研究在 Yangzhong 县被进行的方法，江苏省，中国。题目是用在人口分布和生活方式上包括了问题的一张结构化的问询表的会见 by trained 接见者。XRCC1 遗传型用聚合酶链反应被分析基于的限制碎片长度多型性(PCR-RFLP ) 试金。无条件的逻辑回归分析被用来与 XRCC1 多型性和生活方式相关的因素为 ESCC 的协会计算调整机会比率(aORs ) 和 95% 信心间隔(CI ) 。结果两河水和白酒吸入历史喝显著地被联系[SW1 ] 与在有 4.20 的 aORs 的人之中的 ESCC 的增加的风险(95% CI：2.90-6.07 ) 并且 2.03 (95% CI：1.43-2.89 ) 分别地。为女人，相应机会比率是 8.37 (95% CI：5.09-13.75 ) 为河水喝酒并且 12.78 (95% CI：2.69-60.69 ) 为长期的存储米饭吸入。在 XRCC1 G28152A 多型性为潜在的 confounders 被调整以后，有 GA 和 AA 遗传型的题目为 ESCC 有增加的风险(aOR：1.21， 95% CI：0.93-1.56 ) ，与有 GG 的题目相比，遗传型，和在长期的存储米饭和 XRCC1 G28152A 多型性的吸入之间的一个积极趋于增加的相互作用被观察(P=0.009 ) 。结论我们的调查结果建议那两个生活方式相关的因素，包括的喝的河水，长期的存储米饭和酒精吸入，和 XRCC1 G28152A 多型性是为 ESCC 的可能的风险因素，并且 XRCC1 G28152A 多型性在中国人民之中在 ESCC 的风险上修改了长期的存储米饭吸入的效果。

英文摘要：

Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene （XRCC1） and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma （ESCC） in China. Methods A population-based case-control study of 432 cases and 915 controls was conducted in Yangzhong County, Jiangsu Province, China. Subjects were interviewed by trained interviewers using a structured questionnaire that included questions on demographics and life style. XRCC1 genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism （PCR-RFLP） assay. Unconditional logistic regression analysis was used to calculate adjusted odds ratios （aORs） and 95% confidence intervals （CIs） for associations of ESCC with XRCCI polymorphisms and lifestyle-related factors. Results Both the drinking of river water and alcohol intake history were significantly associated with an increased risk of ESCC among men with aORs of 4.20 （95% Ch 2.90-6.07） and 2.03 （95% Ch 1.43-2.89）, respectively. For women, the corresponding odds ratios were 8.37 （95% CI： 5.09-13.75） for river water drinking and 12.78 （95% CI： 2.69-60.69） for long-term stored rice intake. After the XRCC1 G28152A polymorphism was adjusted for potential confounders, subjects with GA and AA genotypes had an increased risk for ESCC （aOR： 1.21, 95% CI： 0.93-1.56）, compared with subjects with a GG genotype, and a positive multiplicative interaction between intake of long-term stored rice and the XRCC1 G28152A polymorphism was observed （P=O.009）.Conclusions Our findings suggest that both lifestyle-related factors, including drinking river water, long-term stored rice and alcohol intake, and the XRCC1 G28152A polymorphism were possible risk factors for ESCC, and that the XRCC1 G28152A polymorphism modified the effect of long-term stored rice intake on the risk of ESCC among Chinese people.