中文摘要：

一氧化氮（NO）作为气体明星分子和信号分子,在哺乳动物体内不同的生理调节过程中具有非常重要的作用,尤其是哺乳动物卵巢功能的调控.一氧化氮合酶（NOS）是NO合成的限速酶,是调节NO合成的关键环节,也是NO依赖性功能调控的重要环节.因此,调节NOS转录/合成的信号通路对哺乳动物卵巢NO依赖性功能具有至关重要的调控作用.最近的研究发现,缺氧诱导因子（HIF）作为转录因子,参与许多与缺氧相关靶基因的转录调控,如NOS和血管内皮生长因子（VEGF）等.本文一方面描述了NO合成及其调控的分子机制,另一方面阐明了HIF作为转录因子对NOS的转录调控,从而揭示HIF在NO依赖性卵巢功能调控中的重要作用,同时为进一步研究哺乳动物卵巢功能的调控提供新的研究方向和理论基础.

英文摘要：

Nitric oxide（NO）,as a gas star molecule and signaling molecule,plays a very important role in different physiological processes in mammals,especially in the regulation of mammalian ovarian functions.Nitric oxide synthase（NOS） is the key rate-limiting enzyme in NO synthesis,which is very important to NO-dependent functional regulation.Therefore,the regulation of the signaling pathway of NOS transcription/synthesis plays a crucial role in mediating NO-dependent function in mammalian ovaries.Recent studies have found hypoxia-inducible factor（HIF）,as a transcription factor,is involved in many transcriptional regulations of hypoxia-associated target genes,like NOS and vascular endothelial growth factor（VEGF）,etc.The present article describes the molecular mechanism of NO synthesis and its regulation,and illustrates how the transcription factor HIF regulates the transcription of NOS.All of these further revealed that HIF plays a important role in the regulation of NO-dependent ovarian function.At the same time,it provides new research directions and theoretical basis for further studying the regulation of mammalian ovarian functions.