中文摘要：

建立了高效液相色谱法测定栀子苷和栀子苷元的血浆蛋白结合率。采用C18色谱柱，流动相为乙腈-0．05％磷酸（15：85），检测波长238nm。测得栀子苷、栀子苷元与小牛血清白蛋白、人血清白蛋白和大鼠血浆的蛋白结合率分别为（38．1±4．2）％和（63．4±1．2）％，（17．6±4．9）％和（81．5±6．2）％，以及（24．5±3．8）％和（94．6±1．0）％。结果表明栀子苷元与血浆蛋白的结合力高于栀子苷。

英文摘要：

An HPLC method was established for the determination of plasma protein binding rates of geniposide and genipin. A C18 column was used with the mobile phase of acetonitrile-0.05 % phosphoric acid （15 ： 85） at the detection wavelength of 238 nm. The plasma protein binding rates of geniposide and genipin with BSA, HSA and rat plasma were （38.1±4.2） % and （63.4±1.2） %, （17.6±4.9） % and （81.5±6.2） %, （24.5±3.8） % and （94.6±1.0） %, respectively. The results showed that the binding capacity of genipin with the above plasma proteins was higher than that of geniposide.