中文摘要：

钙调蛋白（Calmodulin,CaM）对细胞内钙离子（Ca）的浓度具有重要的调节作用。Ca/CaM/钙调蛋白激酶Ⅱ是心肌细胞CaM信号转导的重要途径之一。钙调蛋白激酶Ⅱ（CaMKⅡ）是一种重要的丝/苏氨酸蛋白激2＋酶,其表达直接影响心肌细胞的功能和电生理学特性。CaMKⅡ作为Ca调节通路的组成成分,在过度激活时会通过增加钙通道的开放频率而引发心律失常。而且在缺血再灌注初期,CaMKⅡ活性的增加可触发再灌注性心律失常,CaMKⅡ阻断剂对钙超载损伤的心肌细胞有保护作用。

英文摘要：

Calmodulin （CAM） plays an important role in the regulation of intracellular calcium （Ca^2＋） concentration, Ca^2＋/CaM/CaMK Ⅱ is one of the most important CaM signal transduction pathways in the cardiac myocytes. Ca^2＋/CaM-dependent protein kinase Ⅱ （CaMK Ⅱ ） is an important serine / threonine protein kinase that directly affects the function and electrophysiological properties of myocardial cells. CaMK Ⅱ, as a component of the pathway, can increase the open frequency of calcium channel when excessively activated, and cause arrhythmia. Also, early in ischemia-reperfusion, increased CaMK Ⅱ activity may trigger reperfusion arrhythmias, CaMK Ⅱ antagonist has a protective effect on myocardial calcium overload injury.