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中文摘要：
肝细胞性肝癌（hepatocellular carcinoma,HCC）是最常见的恶性肿瘤之一,大部分发生在发展中国家.HBV感染是HCC发生的重要危险因素.HBV可通过多种机制引起和促进HCC发生：HBV感染引起免疫反应导致反复肝脏炎症、损伤、再生和疤痕修复反应,形成炎症、纤维化、免疫缺陷微环境;HBV可整合入宿主肝细胞基因组引起遗传学改变和HCC相关基因表达的变化;HBV表达多种活性蛋白,特别是HBx及S蛋白,可通过反式激活和与细胞内特定蛋白相互作用、活化多种信号途径、诱导异常的表观遗传改变促进HCC发生;此外,HBV突变也影响HBV相关HCC的发生.
英文摘要：
Hepatocellular carcinoma （HCC） is one of the most common cancer worldwide.Most of the HCC occur in developing countries.Chronic hepatitis B virus （HBV） infection is an important risk factor for HCC development.HBV induces immune-mediated chronic hepatitis,liver injury,regeneration and scar forming responses,leading to an inflammatory,fibrotic and immune deficient microenvironment.HBV may integrate into host genome,inducing genetic abnormality and altering the expression of HCC-related genes.HBV also expresses active proteins such as X （HBx） and S proteins,which may trans-activate HCC-related proteins expression,interact with intracellular specific proteins,activate a variety of signaling pathways,and induce aberrant epigenetic modifications.HBV mutation also has impact on HBV related HCC development.
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