中文摘要：

在毒素热和血壅滞症候群的一个兔子模型的血栓，煽动性的反应，和织物损坏的索引上的目的将为激活血循环(ABC ) 并且为激活血循环并且除去观察中国药的规章的效果。 54 只兔子被使随机化进正常控制组，的方法为组建模， simvastatin 组( simvastatin ， 0.93 mg/kg 每天)， ABC 组[ Xiongshao 囊()， 0.07 g/kg 每天]，并且 ABCD 组[ Xiongshao 囊， 0.07 g/kg 每天，并且 Huanglian 囊()， 0.14 g/kg 每天]。都除了正常控制，组收到了牛的浆液白朊的单个注射并且用高脂肪的食谱被喂 6 个星期。在给高脂肪的食谱中的星期 4 个的结束， endoxitin 的剂量被耳朵静脉注射给，并且一个使随机化的 2 星期的处理被开始。在处理的结束，血类脂化合物，传播 endothelial 房间，和大动脉的拱门的病理学的变化被估计。矩阵 metalloproteinases (MMP-9 )的浆液层次，到 metalloproteinase ( TIMP-1 )的织物禁止者，小粒膜 protein-140 ( GMP-140 )， plasminogen 使活跃之物 inhibitor-1 ( PAI-1 )，高敏感的C反应的蛋白质( hs-CRP )， interleukin-6 ( IL-6 )，和肿瘤坏死因素--(TNF-)被决定。结果与模型组，相比， ABCD 组在传播 endothelial 房间的数字显示出减少的浆液 triglyceride (TG ) 水平，在在大动脉的拱门的病理学的变化的改进，和减小(4.00 潲整瑣湩 ? 潢祤映湵瑣潩獮

英文摘要：

Objective： To observe the regulatory effect of Chinese drugs for activating blood circulation （ABC） and for activating blood circulation and detoxifying （ABCD） on indices of thrombosis, inflammatory reaction, and tissue damage in a rabbit model of toxin-heat and blood stasis syndrome. Methods： Fifty-four rabbits were randomized into the normal control group, model group, simvastatin group （simvastatin, 0.93 mg/kg per day）, ABC group [Xiongshao Capsule （~ff_）, 0.07 g/kg per day], and ABCD group [Xiongshao Capsule, 0.07 g/kg per day, and Huanglian Capsule （-~L~t）, 0.14 g/kg per day]. All except the normal control group received a single injection of bovine serum albumin and were fed with high-fat diets for 6 weeks. At the end of week 4 of giving high- fat diets, a dose of endoxitin was given by ear vein injection, and a randomized 2-week treatment was initiated. At the end of treatment, blood lipids, circulating endothelial cells, and the pathological changes of the aortic arch were assessed. The serum levels of matrix metalloproteinases （MMP-9）, tissue inhibitors to metalloproteinase （TIMP-1）, granule membrane protein-140 （GMP-140）, plasminogen activator inhibitor-1 （PAl-l）, high-sensitivity C-reactive protein （hs-CRP）, interleukin-6 （IL-6）, and tumor necrosis factor- ~ （TNF- oL ） were determined. Results： Compared with the model group, ABCD group showed decreased serum triglycaride （TG） level, improvement in the pathological change in the aortic arch, and reduction in the number of circulating endothelial cells （4.00_＋ 1.41 per 0.9 p~ L for ABCD group vs 7.83_＋ 1.72 per 0.9 μL for the model group）. In addition, the levels of serum GMP-140, PAl-l, and IL-6 in ABCD group were also significantly reduced [0.79＋0.20 ng/mL, 5.23± 1.39 ng/mL, 40.64 ± 10.11 pg/mL for ABCD group vs 1.08 ± 0.31 ng/mL, 7.28± 2.01 ng/mL, 54.44 ± 13.56 pg/mL for the model group, respectively, P〈0.05]. A trend showing improvement in the indices of thrombosis, inflammat