NO ASSOCIATION BETWEEN TUMOR NECROSIS FACTOR ALPHA AND OBSESSIVE COMPULSIVE DISORDER IN CHINESE HAN POPULATION
- ISSN号:1672-0458
- 期刊名称:《现代电生理学杂志》
- 时间:0
- 分类:R749[医药卫生—神经病学与精神病学;医药卫生—临床医学]
- 相关基金:Supported by National High Technology Research and Development Program of China (863 Program,2007AAO2Z420 and 2008AA02Z412); Joint Key Project of New Frontier Technology in Shanghai Municipal Hospitals(SHDC12006105); the National Natural Science Foundation of China(30770772); Municipal Committee of Shanghai Science and Technology(09411968200); Doctorate Foundation of Shanghai Jiaotong University School of Medicine (BXJ201047)
中文摘要:
Objective To investigate association between tumor necrosis factor alpha (TNF-α) and obsessive compulsive disorder (OCD) in Chinese Han population.Methods Plasma concentrations of TNF-α were measured in 61 drug-free patients who fulfilled DSM-Ⅳ criteria for OCD and 93 healthy controls.TNF-α concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).Two polymorphisms of TNF-α gene were investigated in the same patients and healthy controls:-308 G/A and-238 G/A.The allelic and genoty...