中文摘要：

目的：探讨超声造影定量分析肝动静脉渡越时间对结直肠癌肝转移的预测价值。方法：研究对象包括58例明确诊断为结直肠癌肝转移的患者（转移组），48例具有结直肠癌史同时无肝内转移的患者（待查组）及39例健康志愿者（对照组）。所有研究对象均行超声造影检查，分析肝动脉及肝静脉到达时间并计算其差值记为肝动静脉渡越时间（HAVTT）。待查组患者在3-6个月后行超声造影检查及增强CT／MRI检查来判断是否发生肝内转移。结果：转移组HAVTT较正常组明显缩短（6．58SVs10．75s，P=0．0000）。以HAVTT小于8秒为标准诊断结直肠癌肝转移，准确性、敏感性及特异性分别为97．93％、96．55％及100％。以HAVTT小于8秒为标准预测结直肠癌肝转移，准确性、敏感性及特异性分别为93．75％、66．67％及95．56％。结论：HAVTT可用来预测结直肠癌肝转移。HAVTT缩短者需进一步检查或密切随访。

英文摘要：

Objective： The aim of this study was to assess the value of hepatic transit time in suggesting coming colorectal liver metastases by contrast-enhanced ultrasonography（CEUS）. Methods： Fitly-eight patients with identified colorectal liver metastasis （Gmet）, forty-eight patients without liver metastasis （Gunc） who had proven colorectal cancer, and thirty-nine normal volunteers （Gcon） were in- cluded in this study. Every subject was examined by CEUS. The arrival times of the hepatic artery （HAAT） and the hepatic vein （HVAT） were measured and the difference between them was calculated as hepatic artery-vein transit time （HAVTT）. Patients in Gunc were given CEUS examination and enhanced CT/MRI examination after 3-6 months. Results： HAVTTs in Greet were significantly shorter than those in Gcon. A normal cut-offpoint of 8 sec in the HAVTTs could distinguish Gmet and Gcon with an accuracy, sensitivity and specificity to be 97.93 %, 96.55 % and 100 % respectively. For Gunc, the accuracy, sensitivity and specificity were 93.75 %, 66.67 % and 95.56 % re- spectively, when an HAVTT less than 8 sec was used to predict colorectal liver metastasis. Conclusion： HAVTT may be a useful tool in monitoring colorectal liver micrometastases. If one patient with a primary colorectal cancer has a shorter HAVTT, it suggests that he/she need extra examination and therapy.