中文摘要：

阿尔茨海默病（Alzheimer＇s disease,AD）是以记忆和其他高级认知功能下降为特征的神经退行性疾病.早期的神经影像学研究通常是探索AD患者局部脑区的结构和功能变化.随着多模态神经影像技术和人脑连接组学研究方法的发展,研究者已经能够考察AD患者脑结构和功能连接通路.采用这些方法,最近的研究已经发现,AD患者脑网络的连接强度、网络效率、模块化组织和核心脑区连接的下降,并发现这些变化与患者的记忆评分等密切相关.这些新方法和新技术的出现不仅提供了新颖的观点来解释AD病的脑区失连接病理生理机制,而且发现的AD异常脑连接模式可能作为敏感特征应用于AD早期辅助诊断的影像标记物研究.特别重要的是,研究表明,在AD患者脑神经网络出现的异常连接模式,在AD前期即轻度认知障碍期患者中也已出现,表明了将AD影像学研究的重点前移到AD前期这一可治疗阶段的重要性和迫切性.

英文摘要：

Alzheimer＇s disease （AD） is a progressive, neurodegenerative disease characterized by impaired memory and other cognitive functions. Previous neuroimaging studies have demonstrated regional structural and functional changes. Recent progressions on multi-modal imaging techniques and human brain connectome methods have allowed us to explore alterations of structural and functional networks in AD. Using these approaches, many studies have discovered AD-related network disruption, including connectivity strength, network efficiency, modular structure and network hubs. These findings provide novel insights into the understanding of AD notion of network disintegration and might lead to uncover disease biomarker for early diagnosis in AD. Most importantly, these findings in AD have been also demonstrated in the individuals at risk for AD （e.g., mild cognitive impairment）, suggesting that the neuroimaging studies of AD should be moved into the prodromal stage of AD from the dementia stage.