中文摘要：

目的：探讨IL-17、IL-23参与变应性鼻炎（AR）和非变应性鼻炎（NAR）发病的可能作用。方法：选取AR患者156例（AR组）、NAR患者59例（NAR组）、健康志愿者60例（对照组）。对AR组和NAR组的所有患者进行鼻部症状的VAS评分;采集全部研究对象外周血及鼻腔分泌物,检测其中IL-17、IL-23的表达水平。结果：AR组与NAR组患者VAS评分差异无统计学意义（P〉0.05）;AR组与NAR组血清及鼻腔分泌物中的IL-17和IL-23含量均高于对照组,差异有统计学意义（P〈0.05）;AR组和NAR组血清及鼻腔分泌物中IL-17、IL-23的表达具有相关性,差异有统计学意义（P〈0.05）。结论：IL-17和IL-23是AR和NAR的重要细胞因子,IL-23/IL-17轴在AR和NAR发病机制中发挥重要作用。

英文摘要：

Objective：To investigate the effect of IL-17 and IL-23 in the pathogenesis of allergic rhinitis（AR）and non allergic rhinitis（NAR）.Method：Selected 156 cases of patients with allergic rhinitis（AR group）and 59 cases of patients with non-allergic rhinitis（NAR group）,60 cases of healthy people（control group）.All cases in AR group and NAR groups were evaluated by a visual analog scale（VAS）score of nasal symptoms.Collected peripheral blood and nasal secretions in all cases and then detected IL-17 and IL-23 expression levels.Result：There was no significant difference in VAS score of AR group and NAR group（P〉0.05）.IL-17 and IL-23 levels of serum and nasal secretions in AR group and NAR group were both higher than control group,with a highly significant difference（P〈0.05）.The research showed a clear correlation between expression of IL-17 and IL-23 both in serum and nasal secretions of AR group and NAR（P〈0.05）.Conclusion：IL-17 and IL-23 may be important cytokines and IL-23/IL-17 pathway may play a significant role in the pathogenesis of allergic rhinitis and non-allergic rhinitis.