中文摘要：

采用水热法合成了水溶性良好的吡啶二羧酸根（DPA）敏化LaF3：Tb（DPA-LaF3：Tb）纳米粒子, 该粒子的发光强度大且光学性能稳定. X射线衍射分析表明, 合成了单一相六方晶系的LaF3晶体; 透射电子显微镜结果表明, 所合成粒子分散性良好, 粒径约为15 nm. 测得合成粒子在水相中的发光寿命为2.95 ms. 以DPA-LaF3：Tb纳米粒子为发光探针, 基于DNA对纳米粒子的发光猝灭, 实现了对DNA的定量测定, 该方法的线性范围为0.083-13.0 μg/mL; 检出限为0.02 μg/mL; 并研究了共存物质对DNA测定的干扰.

英文摘要：

Lanthanide nanoparticles have been used in bioanalysis due to their excellent luminescence properties. Herein, dipicolinate（DPA） sensitized LaF3：Tb（DPA-LaF3：Tb） nanoparticles with good water solubility were synthesized by hydrothermal method, which emit strong and stable luminescence. X-Ray diffraction（XRD） pattern showed that the particles were single-phase LaF3 crystals in hexagonal system, and transmission electron microscopy（TEM） image showed a good dispersion of DPA-LaF3：Tb nanoparticles with nearly uniform size of about 15 nm. The lifetime of the particles in water was measured 2.95 ms. It was found that DNA could quench effectively the luminescence of the particles. Based on the luminescence quench, the determination of DNA was realized with the linear range of 0.083~13.0 μg/mL and the detection limit of 0.02 μg/mL. Moreover, the interference of coexistence substances to the determination of DNA was studied.