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犬尿氨酸羟化酶选择性抑制剂L-3-(邻甲氧基苯甲酰基)丙氨酸的简捷合成
  • ISSN号：0567-7351
  • 期刊名称：《化学学报》
  • 时间：0
  • 分类：TQ246[化学工程—有机化工]
  • 作者机构：[1]中国科学院上海有机化学研究所生命有机化学国家重点实验室, [2]中国科学院上海有机化学研究所生命有机化学国家重点实验室 上海
  • 相关基金：国家自然科学基金(Nos.20425205,20321202)资助项目.
作者： 马向东[1], 姚祝军[2]
关键词： L-3-(邻甲氧基苯甲酰基)丙氨酸, Weinreb酰胺, 芳基锂试剂, 犬尿氨酸酶, 抑制剂, L-3-（o-methoxybenzoyl）alanine, Weinreb amide, aryl lithium, kynurenine hydroxylase, inhibi- tor
中文摘要：

从Boc-保护氨基的天冬氨酸苄酯出发,通过5步反应简捷地合成了犬尿氨酸羟化酶的选择性抑制剂L-3-(邻甲氧基苯甲酰基)丙氨酸(o-MBA).其中关键反应为锂试剂对Weinreb酰胺的亲核取代反应.

英文摘要：

A concise five-step synthesis of L-3-(o-methoxybenzoyl)alanine, a selective kynurenine hy- droxylase inhibitor is described starting from commercially available 4-benzyl L-N-(tert-butoxycarbonyl) aspartate. Aryl lithium addition to the corresponding Weinreb amide successfully served as the key step.

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期刊信息
  • 《化学学报》
  • 北大核心期刊（2014版）
  • 主管单位:中国科学院
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：周其林
  • 地址：上海市零陵路345号
  • 邮编：200032
  • 邮箱：hxxb@sioc.ac.cn
  • 电话：021-54925085
  • 国际标准刊号：ISSN：0567-7351
  • 国内统一刊号：ISSN：31-1320/O6
  • 邮发代号:4-209
  • 获奖情况:
  • 首届国家期刊奖,第二届国家期刊奖提名奖,中国期刊方阵“双高期刊”
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:28694