目的观察滋肾宁心法治疗绝经综合征心肾不交证的临床疗效。方法将51例患者分为治疗组和对照组,治疗组采用滋肾宁心之“宁更丹Ⅱ号方”治疗,对照组采用“坤宝丸”中成药治疗,2组疗程均为2个月。治疗前后测定血清雌二醇(E2)、卵泡生成素(FSH)、黄体生成素(LH)水平。结果治疗组显效率为56.67%,对照组显效率为42.86%,治疗组的总疗效优于对照组。治疗组的主要临床症状均有明显的改善,其中烘热汗出、五心烦热、心悸、口干咽燥、腰酸膝软等症状改善明显,有效率均在90%以上。治疗组和对照组治疗后FSH、LH均较治疗前有下降趋势,但没有统计学意义(P〉0.05),E2治疗后较前有所上升,也没有统计学意义(P〉0.05)。结论滋肾宁心法对绝经综合征心肾不交证患者临床症状有明显的改善作用,对E2、FSH、LH变化有一定影响。
Objective To observe the curative effect of the therapy of enriching kidney and calming heart in the treatment of the pattern of heart-kidney non-interaction of menopausal syndrome. Methods The cases (n =51 ) were divided into the treatment group treated with Ninggeng Pellets II (with the actions of en- riching kidney and calming heart) and the control group treated with Kunbao Pills. The therapeutic course was 2 months. The levels of serum E2, FSH and LH were detected before and after the treatment. Results The marked efficiency rate was 60% in the treatment group and 42. 86% in the control group. The difference between two groups was significant (P 〈 0. 05). The symptoms, such as hot flushes and swea- ting, vexing heat in the chest, palms and soles, palpitation, dryness in mouth and throat, and soreness of waist and knees, were relieved significantly with an effective rate being over 90%. The level of FSH tended to reducing in two groups after the treatment but without statistical significance (P 〉 0. 05). The level of E2 increased a little but without statistical significance (P 〉 0. 05) too. Conclusion The therapy of enriching kidney and calming heart can significantly relieve the symptoms in the patients with the pattern of heart- kidney non-interaction of menopausal syndrome and influence on the changes of E2, FSH and LH.