中文摘要：

目的检测炎症性肠病（IBD）即溃疡性结肠炎（UC）及克罗恩病（CD）患者外周血淋巴细胞表面白介素-23（IL-23）受体的表达情况，并讨论其在疾病发生中的意义。方法收集30例UC患者、16例CD患者和30例正常对照者的外周血，分离外周血单个核细胞（PBMC），采用三色流式细胞术检测IBD患者外周血CD4^＋T、CD8^＋T和CD56^＋NK细胞表面IL-23受体（IL-23R）的表达，并与正常外周血比较。结果UC及CD患者外周血中CD4^＋T、CD8^＋T、CD56^＋NK细胞表面IL-23R的表达明显高于对照组（P〈0．05）。结论IBD患者外周血淋巴细胞表面IL-23R的表达增高，提示IL-23R在IBD的发病过程中起重要作用。

英文摘要：

Objective To detect the expression of IL-23 receptor in T lymphocytes and NK cells in peripheral blood mononuclears （PBMC） from patients with inflammatory bowel disease （IBD） as well as its significance in the pathogenesis. Methods PBMC, isolated from 30 patients with UC, 16 patients with CD and 30 healthy controls, were used to determine the expression of IL-23 receptor in T lymphocytes and NK cells by flow cytometry. The surface of lymphocytes was determined by three-colour flow cytometry in inflammatory bowel disease patients, and the results were compared with those of normal peripheral blood. Results The expression of IL-23R on peripheral CD4^＋ T, CD8^＋ T and CD56^＋ NK cells of patients was obviously higher than that in the control group. Conclusion The expression of IL-23R on T lymphocytes and NK cells of patients with IBD was increased, suggesting that IL-23 receptor plays an important role in the pathogenesis of IBD.