目的:探讨鱼尾葵花粉过敏的变应性鼻炎(AR)患者中血清总IgE、特异性IgE和变应原皮肤试验之间的关系。方法:选择429例对鱼尾葵花粉过敏的AR患者为实验组,243例健康体检者为对照组。实验组进行皮肤试验和特异性IgE水平检测,鱼尾葵花粉特异性IgE采用BSA—ELISA法;所有个体均检测血清总IgE水平。结果:实验组血清总IgE的阳性率明显高于对照组的阳性率(分别为66.2%和15.6%,P〈0.01);实验组皮肤试验与血清特异性IgE之间差异无统计学意义(x^2=0.7588,P〉0.05);实验组血清特异性IgE和总IgE之间差异有统计学意义(x^2=50.639,P〈0.01);海口长居患者与来海南旅游过客血清特异性IgE之间、总IgE之间差异均无统计学意义(P〉0.05)。结论:变应原皮肤试验与检测鱼尾葵花粉特异性IgE2种方法在诊断鱼尾葵花粉过敏的AR中有重要作用,检测血清总IgE对鱼尾葵花粉过敏的AR患者的诊断有参考价值,鱼尾葵花粉过敏的AR患者IgE的阳性率与接触时间之间的关系,有待进一步研究。
Objective:Exploring the relationship between total and specific IgE in serum and allergen skin test of carvota mitis pollen-induced allergic rhinitis patients. Method.. Four hundred and twenty-nine carvota mitis pollen-induced allergic rhinitis patients and 243 healthy control subjects were recruited. The experimental group carried out skin tests, and pollen-specific IgE were also examined by BSA-ELISA method. Total IgE in serum of all of the subjects were determined by ELISA. Result:The positive rate of the total IgE level of the patients were much higher than those of the controls(66.2 % vs. 15.6 %, P〈0.01). No statistically significance was found between the positivity of skin test and serum specific IgE of the experimental group(x^2 = 0. 758 8,P〉0.05). The difference between serum-specific IgE and total IgE was statistically significant(x^2= 50. 639, P〈0.01). There was no statis- tical significance of specific IgE and the total IgE in serum between long term residents in Haikou and Hainan Tourisms (P〉0. 05). Conclusion:Allergen skin test and carvota mitis pollen-specific IgE are two effective methods for the diagnosis of carvota mitis pollen-induced allergic rhinitis. The detection of total IgE in serum of carvota mitis pollen-induced allergic rhinitis provides a reference value for diagnosis. The relationship between concentration of IgE in serum of the carvota mitis pollen-induced allergic rhinitis and allergen contact duration is waiting for further study.