中文摘要：

背景孤独性光谱混乱(ASD ) 包括孤独性， asperger 症候群(作为) 并且弥漫发展不那样混乱不指定了(PDD 没有) ，正在破坏在社会相互作用，行为的重复模式，和限制兴趣和活动导致赤字的童年的 neurodevelopmental 混乱。单个光子排放计算了断层摄影术(SPECT ) 一种普通技术被用来测量地区性的服的血流动(rCBF ) 。然而，几研究用 SPECT 与 ASD 在孩子测量了 rCBF 调查结果是不和的。另外，在这些研究使用的题目的多数是 autistic。在这研究，我们试图与使用 SPECT.Methods A Technetium-99m-ethyl cysteinate 的 ASD 在孩子在 rCBF 调查变化更暗淡(99mTc-ECD ) 大脑 SPECT 学习在由 23 个孩子组成的一个 ASD 组上被执行(3 个女孩和 20 个男孩；吝啬的年龄(7.2ndependent 因素。有固定任务 / 位置的工人的 PNEL ((86.53

英文摘要：

Background Autism spectrum disorders （ASD）, which include autism, asperger syndrome （AS） and pervasive developmental disorder-not otherwise specified （PDD-NOS）, are devastating neurodevelopmental disorders of childhood resulting in deficits in social interaction, repetitive patterns of behaviors, and restricted interests and activities. Single photon emission computed tomography （SPECT） is a common technique used to measure regional cerebral blood flow （rCBF）. Several studies have measured rCBF in children with ASD using SPECT, however, findings are discordant. In addition, the majority of subjects used in these studies were autistic. In this study, we aimed to investigate changes in rCBF in children with ASD using SPECT.Methods A Technetium-99m-ethyl cysteinate dimmer （99mTc-ECD） brain SPECT study was performed on an ASD group consisting of 23 children （3 girls and 20 boys; mean age （7.2±3.0） years） who were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition （DSM-Ⅳ） criteria and an age-matched control group with 8children （1 girl and 7 boys, mean age （5.5±2.4） years）. Image data were evaluated with Statistical Parametric Mapping,5th version （SPM5）. A Student＇s t test for unpaired data was used to compare rCBF and asymmetry in the autism and corresponding control group. The covariance analysis, taking age as covariance, was performed between the ASD and control group.Results There was a significant reduction in rCBF in the bilateral frontal lobe （frontal poles, arcula frontal gyrus） and the bilateral basal ganglia in the autism group, and a reduction in the bilateral frontal, temporal, parietal, legumina nucleus and cerebellum in the AS group compared to the control. In addition, asymmetry of hemispheric hypoperfusion in the ASD group was observed. Inner-group comparison analysis revealed that rCBF decreased significantly in the bilateral frontal lobe （42.7%）, basal nucleus （24.9%） and temporal lobe （22.8%?