中文摘要：

房间膜在细胞的活动起一个关键作用。鱼红血球，更低的脊椎动物的起核心作用的红血球的原型，有椭圆的原子核和在尺寸更大的大部分的主要卵形的、两面凸的磁盘比人的红血球。在鱼和人的红血球之间在尝试组织揭示膜的关联，我们在 situ 使用了与单个分子的力量光谱学相结合在伪土著人条件下面学习鲫鱼鲤鱼红血球的膜结构的原子力量显微镜(AFM ) 。我们的结果在鲫鱼鲤鱼红血球膜揭示了蛋白质的不对称的分发：没有任何蛋白质，膜的外部传单是相当光滑的，而膜的内部传单与稠密的蛋白质是很不平的。鱼红血球膜结构的不对称现象与人的红血球膜结构的半马赛克模型一起适合很好。在人和鱼红血球之间的膜结构的这类似扩大红血球膜结构的半马赛克模型到大量种类。

英文摘要：

Cell membranes play a key role in cellular activities. Fish erythrocytes, prototype of the nucleated erythrocytes of lower vertebrates, are predominantly oval, biconvex discs with elliptical nucleus and much larger in size than human erythrocytes. In attempts to disclose the correlation of membrane structure between fish and human erythrocytes, we used in situ atomic force microscope （AFM） combined with single-molecule force spectroscopy to study the membrane structure of Crucian carp erythrocytes under quasi-native conditions. Our results revealed the asymmetric distribution of proteins in Crucian carp erythrocyte membrane： the outer leaflet of membrane is rather smooth without any proteins, whereas the inner leaflet of membrane is very rough with dense proteins. The asymmetry of fish erythrocyte membrane structure fits well with the semi-mosaic model of human erythrocyte membrane structure. This similarity of membrane structure between human and fish erythrocytes extends the semimosaic model of erythrocytes membrane structure to a wider range of species.