中文摘要：

代谢性骨破坏疾病如关节炎、骨质疏松,临床主要表现为骨骼的功能障碍,由于其机制目前仍未完全阐明,临床缺乏有效的治疗方法。调节性T细胞（Tregs）是一群具有免疫抑制功能的T细胞亚群,在免疫系统中起重要作用,体外实验证实Tregs抑制破骨细胞（OC）的分化和功能。在动物模型中,进一步证实Tregs通过抑制破骨细胞的发生而阻断骨质破坏的发生。该文对有关Tregs在骨破坏中的作用最新进展作一综述,以增进对Tregs生物学功能和病理作用的了解。

英文摘要：

Metabolic bone diseases,such as rheumatoid arthritis（RA） and osteoporosis,cause long-term pain and disability.Effective clinical treatment for bone loss is in lacking because the knowledge of molecular mechanisms is understood incompletely.Recently,it has been confirmed that regulatory T cells（Tregs） play a crucial role in suppressing the immune response in the pathogenesis of various autoimmune diseases.In vitro,Tregs directly inhibit the differentiation and function of osteoclasts（OC）.In animal model,it has been certified that Tregs block the destruction of bone through inhibiting OC.This article briefly introduces discuss the biological features of Tregs and summarizes recent advances in the role of Tregs in the pathogenesis and treatment of bone loss.