中文摘要：

目的探讨POEMS综合征患者甲状腺功能减退与腹腔积液的关系及其临床意义。方法回顾性分析2005-01—2014-12长海医院确诊的27例POEMS综合征患者临床与生化检查资料。根据是否合并腹腔积液将患者分为腹腔积液组与无腹腔积液组,比较两组患者间临床和生化检查特征;根据是否合并甲状腺功能减退将患者分为甲状腺功能减退组与甲状腺功能正常组,比较两组间腹腔积液的发生率;分析甲状腺功能减退与腹腔积液的相关性。结果腹腔积液组与无腹腔积液组患者间性别、发病年龄、首发周围神经与内分泌紊乱症状、脾肿大、红细胞沉降率异常率、自身免疫抗体阳性率、浆细胞比例比较无统计学差异（P〉0.05）,首发脏器肿大症状、病程出现内分泌紊乱、肝肿大、甲状腺功能减退、M蛋白、尿本周氏蛋白比较有统计学差异（P〈0.05）;甲状腺功能减退组与正常组患者间腹腔积液发生率比较有统计学差异（χ2=5.56,P〈0.05）;甲状腺功能减退与腹腔积液发生呈正相关（r=0.426,P〈0.05）。结论POEMS综合征合并甲状腺功能减退患者临床易出现腹腔积液症状,了解两者的正相关关系有助于早期预判POEMS综合征合并甲状腺功能减退患者出现腹腔积液的可能。

英文摘要：

Objective To explore the correlation between hypothyroidism and ascites in patients with POEMS syndrome.Methods Clinical and biochemical data of 27 patients with POEMS syndrome admitted into Changhai Hospital from January 2005 to December 2014 were retrospectively analyzed.According to ascites,POEMS syndrome patients were divided into the ascites and non-ascites groups,and the clinical and biochemical characteristics was compared between the two groups.According to the thyroid function,POEMS syndrome patients were divided into the normal thyroid function and hypothyroidism groups,the occurrence of ascites was compared between the two groups.The correlation between the hypothyroidism and ascites was analyzed.Results Between the ascites and non-ascites groups,there were no significant differences in gender,age of onset,the initial symptoms of peripheral nerve and endocrine disorders,splenomegaly,abnormal rate of erythrocyte sedimentation rate（ESR）,positive rate of autoimmune antibody,plasma cells ratio（P〈0.05）,and there were statistically significant differences in the initial symptom of organomegaly,endocrine disorders during the course of diseases,hepatomegaly,hypothyroidism, M protein,urine Bence-Jones proteins（P〈0.05）.Between the thyroid function normal and hypothyroidism groups,there was statistically significant difference in the occurrence of ascites（χ2=5.56,P〈0.05）.The occurrence of ascites was positively correlated with hypothyroidism（r=0.426,P〈0.05）.Conclusions POEMS syndrome patients with hypothyroidism were rather liable to have ascites,and the correlation may be beneficial for early prediction of ascites.