中文摘要：

目的：研究中药治疗花粉症的作用机理。方法：选择50例花粉症患者，口服敏康片，治疗6个月后观察疗效及FceRIβ，IL-4Ra，IL-5Ra，HIM-A基因表达情况，并以20例变应性皮炎和19例正常人为对照，用Northern blot检测FceRIβ，IL-4RA，IL-5Ra的变化。用RT-PCR法检测HLA-A，计算相对光密度值。结果：花粉症组患者症状有明显改善（P〈0．05），治疗前后血清总IgE比较差异有统计学意义（P〈0．01），花粉症组4个基因的表达治疗前与正常人比较，差异均具有统计学意义（P〈0．01），治疗后与治疗前比较差异有统计学意义（P〈0．01）。变应性皮炎组治疗前FceRIβ，IL-4Ra与正常组比较差异有统计学意义（P〈0．05），治疗前后FceRIβ比较，差异有统计学意义（P〈0．05）。鼻炎组、皮炎组HLA-A相对光密度值均较正常组高，两组治疗前后也有不同程度的改善（P〈0．05）。结论：中药可以调整花粉症患者相关基因表达，改善患者过敏体质，缓解临床症状。

英文摘要：

Objective： To evaluate the efficacy of Minkang tablet on gene hay fever. Methods： The trial involved 50 patients with hay fever, 20 patients express in the patients with with atopic dermatitis, Minkang tablet（three capsule, twice a day, 6 months） was given to patients with hay fever（50）,also 19 as normal as control. Results ： The symptom and IgE after medication had difference highly statistically significant before medication. The FceRIβ,IL-4Ra, IL-5Ra, HLA-A related with atopy before and after medication, FceRIβ,IL-4Ra,IL-5Ra, HLA-A in the patients with hay fever and in normal were different highly statistically significant（ P 〈 0.01 ） before medication; and genes express improved significantly （P 〈 0.01 ） after medication. FceRIβ ,IL-4Ra of the patients with atopic dermatitis and in normal were statistically sig- nificant（ P 〈 0.05 ） before medication, FceRIβ improved significantly（ P 〈 0.05 ） after medication. Conclusion： Minkang tablet was effective in controlling gene express on patients with hay fever.