中文摘要：

目的 探索vMIP-Ⅱ结合趋化因子受体的活性住点以便有目的地对其进行改构。方法应用生物信息学方法对影响、vMIP-Ⅱ受体结合的氨基酸残基进行预测分析。结果vMIP-Ⅱ对不同的受体有不同结合位点。其与CC类趋化因子受体结合住点主要在核心骨架，与CXC类趋化因子受体结合位点主要在N端。结论 vMIP- 是一种极佳的趋化因子受体阻断剂类新药开发先导物。

英文摘要：

[Objective] To explore the chemokine binding pmpertles of vMIP-Ⅱ and provide theory basis for further mutation analysis. [Methods] Bioinformative method was used to analyze the binding residues of vMIP-Ⅱ to different receptors. [Results] vMIP-Ⅱ had different specific residues for different receptors binding. Its core mainly contributes the binding to CC chemokines, while its N-terminus contributes the binding to CXC chemokines. [Conclusion] It reveales a good drug template for developing new drug for multiple chemokine receptors blocking.