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Mechanics of DNA packaging and ejection from elastic phage capsid

ISSN号：2095-0349
期刊名称：Theoretical and Applied Mechanics Letters
时间：2013
页码：054003-
分类：TP38[自动化与计算机技术—计算机系统结构;自动化与计算机技术—计算机科学与技术] TV543[水利工程—水利水电工程]
作者机构：[1]Key Laboratory of Mechanics on Environment and Disaster in Western China, the Ministry of Education ofChina, School of Civil Engineering and Mechanics, Lanzhou University, Lanzhou 730000, China
相关基金：This work was supported by the National Natural Science Foundation of China （11032006, 11072093, and 11121202）, the Ph.D. Program Foundation of Ministry of Education of China （20100211110022）, Natioanal Key Project of Magneto-Constrained Fusion Energy Development Program （2013GB110002）, and the Fundamental Research Funds for the Central Universities （lzujbky-2013-1）.
相关项目：超导电-磁-热-力多场耦合非线性力学的基础理论与实验研究

关键词：统计力学模型, DNA链, 弹性变形, 噬菌体, 包装, 弹射, 时间长度, 静电斥力, DNA packaging, ejection, elastic capsid, phage

中文摘要：

This study intends to investigate how the elasticity of a bacterial phage can afect the process of DNA packaging and ejection.For this purpose,we propose a unified continuum and statistical mechanics model by taking into account the efects of DNA bending deformation,electrostatic repulsion between DNA–DNA strands and elastic deformation of the phage capsid.Based on such a model,we derive the quantitative relations between packaging force,elasticity of capsid,DNA length remaining in the capsid,osmotic pressure and ejection time.The theoretically predicted results are found to agree very well with in vitro experimental observations in the literature.

英文摘要：

This study intends to investigate how the elasticity of a bacterial phage can affect the process of DNA packaging and ejection. For this purpose, we propose a unified continuum and statistical mechanics model by taking into account the effects of DNA bending deformation, electrostatic repulsion between DNA-DNA strands and elastic deformation of the phage capsid. Based on such a model, we derive the quantitative relations between packaging force, elasticity of capsid, DNA length remaining in the capsid, osmotic pressure and ejection time. The theoretically predicted results are found to agree very well with in vitro experimental observations in the lit-erature.