中文摘要：

象奇迹(为泡交通国王和膜连接领域的 MAL 和相关蛋白质) 一样的 CKLF (象 chemokine 一样因素)(CMTM ) transmembrane 领域包含是一个新奇基因家庭。这个家庭，的一个成员 CMTM2，也命名的象 chemokine 一样因素总科 2 (CKLFSF2 ) ，在前列腺，髓和外设在睾丸并且中等高度被表示血房间。然而，人的 CMTM2 的功能仍然保持未知。这里，我们发现 CMTM2 起来在 5 调整了对待的 α-dihydrotestosterone (DHT ) LNCaP 房间。我们调查了在 CMTM2 和雄激素受体之间的关系。我们的结果显示出那 CMTM2 提高的调停 DHT 的雄激素受体(AR ) transactivation 和前列腺的表示特定的抗原(PSA ) 。我们也观察到 CMTM2 提高了 AR 蛋白质水平，它被 silencing endogenous CMTM2 表示颠倒，它建议 CMTM2 可能在维持 AR 蛋白质水平起一个重要作用。我们也发现 CMTM2 压制了 Akt 激活。以前的研究显示出那 Akt 能在 Ser210 和 Ser790 的 phosphorylate AR 并且象 AR 的抑制一样导致 AR ubiquitylation 和降级活动。总起来说，压制 Akt 激活并且增加 AR 蛋白质水平可能是为 AR transactivation 的调停 CMTM2 的改进的机制之一。

英文摘要：

CKLF （chemokine-like factor）-Iike MARVEL （MAL and related proteins for vesicle trafficking and membrane link domain） transmembrane domain containing （CMTM） is a novel gene family. One member of this family, CMTM2, also named chemokine-like factor superfamily 2 （CKLFSF2）, is expressed highly in the testis and moderately in the prostate, marrow and peripheral blood cells. However, the function of human CMTM2 remains unknown. Here, we found that CMTM2 was upregulated in 5α-dihydrotestos-terone （DHT）-treated LNCaP cells. We investigated the relationship between CMTM2 and the androgen receptor. Our results showed that CMTM2 enhanced DHT-mediated androgen receptor （AR） transactivation and the expression of prostate specific antigen （PSA）. We also observed that CMTM2 enhanced the AR protein level, which was reversed by silencing endogenous CMTM2 expression, which suggested that CMTM2 might play an important role in maintaining the AR protein level. We also found that CMTM2 suppressed Akt activation. A previous study showed that Akt could phosphorylate AR at Ser210 and Ser790 and lead to AR ubiquitylation and degradation as well as suppression of AR activity. Taken together, suppressing Akt activation and increasing the AR protein level might be one of the mechanisms for the CMTM2-mediated enhancement of AR transactivation.