中文摘要：

目的分析探讨纳美芬对声带息肉切除术患者静脉全麻诱导时应激激素浓度的影响。方法 63例全凭静脉麻醉患者,分为纳美芬组和非纳美芬组,分别于麻醉诱导前（T0）、气管插管前（T1）、气管插管后即刻（T2）、气管插管后5 min（T3）记录收缩压、舒张压、心率,并于各时点采静脉血检测血浆皮质醇（cort）和血管紧张素Ⅱ（ATⅡ）、去甲肾上腺素（NE）和肾上腺素（E）水平。结果麻醉诱导后两组患者HR、SBP、DBP均降低（P〈00.05）;T1、T2、T3三个时间点,两组NE,E,cort和AⅡ水平升高（P〈0.05）。结论纳美芬能更有效地抑制声带息肉切除术患者静脉全麻诱导时的应激反应。

英文摘要：

ObjectiveTo analyze and discuss the effect of nalmefene on stress hormone concentration of patients with vocal cord polyp resection in TIVA. Methods63 patients with TIVA were divided into nalmefene group and non nalmefene group. The systolic blood pressure, diastolic blood pressure and heart rate were recorded at T0、T1、T2 and T3.Venous blood was colected to detect cortl、ATⅡ、NE and E. Results SBP, DBP and HR were decreased in two groups after anesthesia induction（P〈 0.05）.At T1、T2、T3, NE,E,cort和AⅡof two groups were significantly elevated （P〈 0.05）. Conclusion Nalmefene can more effectively inhibit the stress response in patients with vocal cord polyp resection in total intravenous anesthesia.