中文摘要：

目的探讨他汀类药物治疗对急性缺血性卒中后肺炎和卒中转归的影响。方法回顾性纳入急性缺血性卒中后肺炎患者，收集患者人口统计学和临床资料，包括是否应用他汀类药物、肺炎临床特征、抗生素使用时间、中性粒细胞计数等。根据是否使用他汀类药物分为他汀组和对照组。采用改良Rankin量表评价卒中转归。结果共纳入53例急性缺血性卒中后肺炎患者，其中他汀组20例，对照组33例。他汀组年龄以及男性和合并高血压、糖尿病和冠心病的比例与对照组无显著性差异（P均〉0．05）；他汀组治愈率、好转率、无效率和病死率分别为50．00％、35．00％、15．00％和0．00％，对照组分别为15．15％、39．40％、33．30％和15．15％，差异具有统计学意义（P：0．003）。他汀组体温恢复正常[（2．10±3．29）d对（4．61±3．54）d；P=0．002]、肺部哕音消失[（3．60±2．46）d对（7．67±4．09）d；t=-4．019，P=0．000]和抗生素使用[（7．05±3．13）d对（9．73±4．oo）d；t=-2．562，P=0．013]时间均显著短于对照组，而咳嗽、咳痰恢复正常时间与对照组无显著性差异。卒中转归良好组糖尿病（20．83％对55．17％；X2=6．473，P=0．011）、后循环卒中（4．17％对27．59％；P=0．031）以及双侧肺部阴影（29．17％对55．17％；X2=5．705，P=0．017）比例和基线美国国立卫生研究院卒中量表（National Stroke Association NIH Strokescale，NIHSS）评分[（4．00±4．54）分对（10．66±6．33）分；t=1．898，P=0．001]显著低于转归不良组。但转归良好组他汀类药物治疗患者比例与转归不良组无显著性差异（41．67％对34．48％;x^2=0．288，P=0．591）。多变量logistic回归分析显示，糖尿病[优势比（oddsratio，OR）5．146，95％可信区间（confidenceinterval，CI）1．166～22．709；P=0．031]和基线NIHSS评分（OR1．251，95％C／1．080?

英文摘要：

Objective To investigate the effect of statin therapy on pneumonia and stroke outcome after acute ischemic stroke. Methods The patients with pneumonia after acute ischemic stroke were enrolled retrospectively. The demographic and clinical data of the patients were collected, including whether using statins, the clinical features of pneumonia, the days of using antibiotics, and neutrophil count. They were divided into either a statin group or a control group according to whether they used statins or not. Stroke outcome was evaluated with the modified Rankin sole. Results A total of 53 patients with pneumonia after acute ischemic stroke were enrolled in the study, 20 of them were in the statin group and 33 were in the control group. There were no significant differences in age and the proportions of male and complicated with hypertension, diabetes and coronary heart disease between the statin group and the control group （all P〉 0. 05）. The cure rate, improvement rate, invalid rate and mortality in the statin group were 50. 00%, 35.00%, 15.00% and 0. 00%, respectively; and in the control group were 15. 15%, 39.40%, 33.30% and 15.15%, respectively. There were significant differences （P = 0. 003）. The days of temperature returning to normal （2. 10± 3.29 d vs. 4. 61 ± 3.54 d; P =0. 002）, pulmonary rales disappearing （3.60 ±2. 46 d vs. 7. 67 ±4. 09 d; t = -4. 019, P =0. 000） and using antibiotics （7. 05 ± 3. 13 d vs. 9. 73 ± 4. 00 d; t = -2. 562, P = 0. 013） in the statin group were significantly shorter than those in the control group, while there were no significant differences in the days of cough and sputum production returning to normal between the 2 groups. The proportions of diabetes （20. 83% vs. 55. 17% ;X2 =6. 473, P = 0. 011）, posterior circulation stroke （4. 7% vs. 27. 59% ; P = 0. 031） and bilateral lung shadows （29. 17% vs. 55. 17% ;X^2 =5. 705, P =0. 017）, as well as baseline National Stroke Association NIH Stroke Scale （NIHSS） score （4. 00 ± 4. 54 vs. 10. 66