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rt-PA静脉溶栓对脑缺血大鼠血脑屏障通透性及MMP-2、MMP-9活性和表达的影响
  • ISSN号:1673-4165
  • 期刊名称:《国际脑血管病杂志》
  • 时间:0
  • 分类:R743[医药卫生—神经病学与精神病学;医药卫生—临床医学]
  • 作者机构:[1]江苏省启东市第三人民医院神经内科,江苏启东226200, [2]南京大学医学院临床学院南京军区南京总医院神经内科,江苏南京210002
  • 相关基金:国家自然科学基金(30900452)
中文摘要:

目的探讨造成不同亚型急性脑梗死(ACI)短期不良结局的相关性影响因素。方法回顾性分析我院349例急性脑梗死患者,观察脑微出血(CMB)和出血性转化(HT)的发病率、腹围、糖代谢情况及急性缺血性脑卒中试验(TOAST)分型,同时进行神经功能缺损评分(NIHSS),以观察患者短期预后的影响因素。结果 ACI后HT在不同亚型脑梗死中发病率不同,心源性脑栓塞中HT发病率最高,差异有统计学意义(P〈0.05)。HT的危险因素为心源性脑栓塞、不明病因脑梗死及NIHSS评分,低密度脂蛋白、低密度脂蛋白为HT的保护性因素,CMB与HT没有明显相关性。结论早期有效预测ACI发生的指标,及时进行有效的干预措施,对防止病情加重,改善预后具有重要的临床意义。

英文摘要:

Objective To investigate the influencing factors of short-term adverse outcomes in different subtypes of acute cerebral infarction.Methods 349 data of patients with acute cerebral infarction were analyzed retrospectively;the inci dence of CMB and HT were observed,abdominal circumference glucose metabolism and TOAST types were observed too;NIHSS scores were evaluated in order to observe the influencing factors of short-term outcomes.Results The incidence rate of HT in different subtypes of cerebral infarction after acute cerebral infarction was found different,the incidence rate of cardiogenic cerebral embolism was the highest one in HT,the difference was statistically significant(P〈0.05).Cardiogenic cerebral embolism,cerebral infarction of unknown etiology and NIHSS score were found to be the risk factors of HT,low-density lipoprotein and high-density lipoprotein were found to be the protective factors of HT,CMB was found had no correlation with HT.Conclusion Effectively prediction for early indicators of acute cerebral infarction,effectively and time ly take the interventions can prevent exacerbations and improve prognosis,it has important clinical significance.

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期刊信息
  • 《国际脑血管病杂志》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国卫生和计划生育委员会
  • 主办单位:中华医学会 南方医科大学南方医院 海军总医院
  • 主编:
  • 地址:南京江宁区9号信箱
  • 邮编:211135
  • 邮箱:foreignmed@vip.sina.com
  • 电话:025-84121542
  • 国际标准刊号:ISSN:1673-4165
  • 国内统一刊号:ISSN:11-5541/R
  • 邮发代号:28-211
  • 获奖情况:
  • 连续3次被评为江苏省优秀期刊,获军队卫生期刊优秀编辑奖
  • 国内外数据库收录:
  • 中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版)
  • 被引量:4385