中文摘要：

目的：观察基质成纤维细胞活化蛋白（fibroblast activation protein，FAP）在乳腺癌组织的分布特点、表达特征及其变化规律，探讨FAP在乳腺癌发生发展过程中的作用。方法：对术后病理证实为乳腺癌组织的82例病例进行回顾性分析，应用免疫组织化学法检测FAP的表达，探讨FAP在各临床病理参数组的表达分布特征。结果：免疫组化分析显示乳腺癌肿瘤细胞无FAP表达，FAP主要表达于肿瘤细胞周围基质成纤维细胞内。FAP表达与乳腺癌临床分期呈显著正相关（r=0．922，P=0．000）。非浸润性乳腺癌与浸润性乳腺癌FAP表达具有显著统计学差异（t=17．085P=0．000）。有淋巴结转移组较无淋巴结转移组FAP表达量高（t=11．003，P〈0．01）。结论：FAP特异性表达于乳腺癌瘤周基质成纤维细胞，FAP在女性乳腺癌发生、发展、侵袭转移方面起到了重要的作用。

英文摘要：

Objective：To detect expression and significance of fibroblast activation protein （FAP） in the genesis, development and metastasis of female breast cancer. Methods ：Total of 82 female breast cancer tissues proved by op- eration and pathology were analyzed retrospectively. The expression of FAP was detected by immunohistochemistry. The expression of FAP in various clinicopathologic groups was analyzed. Results ： FAP was detected in stromal fibro- blast ceils around the tumor ceils but not in tumor cells. The expression of FAP had a significant positive correlation with clinical stage （ r = 0.922, P = 0. 000 ）. FAP between I （ noninfiltrating carcinoma） and II （ Invasive carcinoma ） showed significant statistical difference（ t = 17. 085 P = 0. 000 ）. The expression of FAP in the group with lymph nodes＇metastasis was higher than the group without lymph nodes＇metastasis（ t = 11. 003 ,P 〈 0.01 ）. Conclusion ： FAP expresses in tumor stromal fibroblast cells. FAP plays an important role in the genesis, development and metastasis of female breast cancer.