中文摘要：

目的评价孕妇产前应用乙型肝炎免疫球蛋白（hepatitis Bimmune globulin，HBIG）阻断乙型肝炎病毒（hepatitis B virus，HBV）宫内传播的效果。方法查阅国内外有关孕妇产前使用HBIG阻断宫内传播的研究，收集出生及1岁婴儿乙肝表面抗原（hepatitis B surface antigen，HBsAg）检测情况，通过Stata12．0软件进行Meta分析，获得合并RR值。结果新生儿随机效应模型干预组与对照组合并RR值为0．37，95％CI：0．23—0．61；1岁婴儿随机效应模型干预组与对照组合并RR值为0．48，95％CI：0．27～0．84。结论应用HBIG200IU可以有效阻断乙肝病毒的官内传播。

英文摘要：

Objective To evaluate the effects of hepatitis B immunoglobulin （HBIG） intrauterine-injection before delivery on interrupting mother-to-child transmission of hepatitis B virus （HBV）. Methods The randomized controlled tri- Ms on HBIG intrauterine injection on interrupting mother-to-child transmission of HBV published from January 1995 to May 2013 were searched. The data were extracted and analyzed by STATA software. Results Results of the meta-analysis indi- cated that the infant HBV infection relative risks with random effects models in the HBIG group and the control group were 0.37（95% Cl：0. 23-0. 61） at birth ,O. 48（95% CI：0.27-0.84）on 1 year. Conclusions Injection of HBIG during pregnancy with possitive HBV can effectively reduce the vertical transmission of HBV.