目的 通过检测动脉粥样硬化(As)不同发展阶段的各种血脂相关指标,来探讨各种检测值与As各个发展阶段的相关性。方法 随机选择健康体检者60例[As(一)组]、脑As无并发症患者24例[As(+)组]、As性脑梗死患者67例[As(++)组],酶化学法测定血清三酰甘油(TG)、总胆固醇(TC),直接法测定低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC),免疫透射比浊法测定载脂蛋白A1(ApoA1)、载脂蛋白B100(ApoB100)、脂蛋白(a)[LP(a)],并对三组的检测值进行统计分析。结果As(+)组与As(-)组比较,TG、TC、LDLC、ApoB100、LP(a)、ApoB100/ApoAI增高(P〈0.05),HDLC、ApoA1降低(P〈0.05)。As(++)组与As(+)组比较,ApoB100、LP(a)、ApoBl00/ApoAl增高(P〈0.05)。As(++)组与As(一)组比较,ApoBl00、LP(a)、ApoBl00/ApoAl显著增高(P〈0.01)。结论TG、TC、LDLC、HDLC、ApoAl、ApoBl00、LP(a)、ApoBl00/ApoAl水平与As的早期发展阶段相关,而且ApoBl00、LP(a)、ApoBl00/ApoAl水平与As的晚期发展阶段相关。
Objective The correlations between the blood lipids and the stages of atherosclerosis (As)were studied via epidemiological investigations. Methods 60 healthy adults ( Group As( - ) ) ,24 atherosclerotic patients with no complication (Group As( + ) ) ,67 atherosclerotic patients with cerebral infarction (Group As( + + ) )were selected random/y, and some of their serum data were measured including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), apolipoprotein A1 ( ApoA100 ), apolipoprotein B100 ( ApoB100 ), lipoprotein (a) ( LP (a) ) and ApoB100/ApoA1 ratio. Results As Group As ( + ) compared with Group As ( - ), TG, TC, LDLC, ApoB100, LP ( a ), ApoB100/ApoA1 increased ( P 〈 0. 05 ), and HDLC,ApoA1 decreased (P 〈0.05). As Group As( + + )compared with Group As( + ),ApoB100,LP(a)and ApoB100/ApoA1 increased ( P 〈 0.05 ). As Group As ( + + ) compared with Group As ( - ), ApoB~o0, LP ( a ) and ApoBlo0/ApoA1 increased significantly ( P 〈 0. 01 ). Conclusions TG, TC, LDLC, HDLC, ApoA1, ApoB100, LP ( a ) and ApoB100/ApoA1 correlated with the early stage of As,what was more,ApoBloo ,LP(a) and ApoB100/ApoA1 correla- ted with the late stage of As.