中文摘要：

目的探讨神经因子诱导的克隆B（NGFI-B）基因和Nur相关因子1（Nurr1）基因在醛固酮瘤中的表达及意义。方法应用实时逆转录-聚合酶链反应（Real time RT-PCR）检测34例醛固酮瘤和13例正常肾上腺组织中神经因子诱导的克隆B基因，Nur相关因子1基因，醛固酮合成酶基因（CYP11B2）和皮质醇合成酶基因（CYP11B1）的mRNA表达水平．结果醛固酮腺瘤组织中NGFI-B基因的mRNA表达量与正常肾上腺组织的差异无统计学意义（P〉0．05），醛固酮腺瘤组织中Nurr1基因呈高表达，与正常肾上腺组织的差异有统计学意义（P〈0．01），醛固酮腺瘤组织中Nurr1基因的表达量与其CYP11B1和CYP11B2的表达量之间明显相关（分别r=0．434，P〈0．01；r=0．376，P〈0．05）。结论孤核受体Nurr1对醛固酮瘤组织中CYP11B2的表达有促进作用，醛固酮瘤组织CYP11B1和CYP11B2的表达是多种转录因子共同作用的结果．

英文摘要：

Objective To investigate the expression and significance of NGFI-B and Nurr1 gene in aldosterone-producing adenomas （APA）. Methods By using real-time RT-PCR assay, the expression of NGFI-B gene, Nurr1 gene, CYP11 B1 and CYP11 B2 was detected in a series of adrenal tissues, including 13 normal adrenals and 34 APA from patients with primary aldosteronism. Results There was no significant difference in the expression of NGFI-B gene between APA and normal adrenal （P 〉 0.05 ）. The expression of Nurrl gene was increased in APA as compared with normal adrenal （P 〈 0. 01 ）. In APA the expression of Nurrl gene was correlated with that of CYP11 B1 and CYP11 B2 （ r = 0. 434, P 〈 0.01 ;r = 0.376,P 〈 0. 05）. Conclusion In APA Nurr1 can promote the expression of CYP11 B2 gene. Several transcription factors are involved in the expression of NGFIB genes.