目的:观察雌激素受体(ERα和ERβ)在非繁殖期成年无蹼壁虎(Gekko swinhonis)心脏的表达并比较性别差异。方法:应用显示雌激素受体的免疫组织化学方法。结果:ERα和ERβ阳性反应均见于无蹼壁虎心肌细胞和成纤维细胞,且受体的表达无性别差异;ERα表达存在明显的心房(11.56±1.67)心室(6.68±1.88)差异(P〈0.01)。结论:雌激素可能是通过ERα主要作用于心房,通过ERβ调节整个心脏的机能;雌激素受体含量与性别无关,可能与生理条件下受体的活性及功能状态有关。
Ahn: To observed the expression of estrogen receptor(ER alpha and ER beta) in the heart of C, ekko swinhonis. Methods: The immuno- histochemical technique for the estrogen receptor was used. Results: The positive ER alpha and beta cells existed in cardiac myocytes and fibroblasts of the atria and the ventricles of C-ekko swinhonis and had no sexual difference. The difference of ER alpha between the atria( 11.56 ± 1. 67) and ventricles(6.68 ± 1.88) was observed in both sexes( P 〈 0.01 ). Conclusion: The atria are probably the main target tissue of estrogen through ER alpha pathway while some functions of whole heart will be regulated by estrogen through ER beta pathway. The sexual differences aren't related to the content of ER. It may be involved in the state of activity and function of ER under the physioloical conditions.