中文摘要：

近些年来癌症发病率不断攀升,引起了人们的普遍关注。由于传统诊疗方法存在弊端,因此开发新型的针对肿瘤组织的多功能的纳米颗粒（如金纳米颗粒、脂质体、聚合物、DNA等）药物输送系统越来越重要。基于生物体的EPR效应或经过表面修饰功能化后,纳米颗粒输送系统可被动或主动靶向到达肿瘤组织,并通过控制温度、pH、超声、光以及酶等激发条件在肿瘤区域实现可控释放。本文简单介绍了肿瘤治疗中常用的具有靶向性、可控释放的纳米颗粒载药系统,系统地描述了纳米颗粒在药物输送系统的最新研究进展,并对今后的发展方向作了展望。

英文摘要：

In recent years, the higher incidence of cancer has aroused wide public concern. Due to the drawbacks of conventional cancer treatment methods, there has been increasing interest in developing new drug targeting delivery systems with multi-functionalized nanoparticles, such as gold nanopartieles, liposomes, polymers, DNA, etc. Base on the enhanced permeability and retention （EPR） effect, the nanoparticles can present both passive and active targeting mechanisms after modified with the targeting biomoleculars on the surface. And the temperature, pH, ultrasound, light and enzymes can all act as incentives for triggered release in tumor regions. This review examines functionalities engineered into nanoparticles recently, including targeting and triggered release of contents, and these properties have raised new opportunities for drug delivery system.