中文摘要：

目的：探讨原发性肝癌（HCC）组织中SOX7mRNA的表达及意义。方法：应用实时荧光定量PCR检测SOX7mRNA在7种肝癌细胞系（HepG2、SNU449、SNU182、SMMC-7721、HUH-7、PLC-PRF-5及Hep3B）和40例HCC及其配对癌旁正常肝组织中的表达。结果：肝癌细胞系中SOX7mRNA低表达或者不表达。HCC组织中SOX7mR-NA表达水平为（1.189±1.213）,正常肝组织中为（1.821±1.718）,HCC组织中的表达水平较正常肝组织降低（t=2.040,P=0.048）。SOX7mRNA的表达与HCC患者的临床分期有关（Z=2.158,P=0.031）。结论：SOX7mRNA表达下调与HCC的发生发展有关。

英文摘要：

Aim：To investigate the expression of SOX7 mRNA in parimay hepatocellular carcinoma（HCC） tissue.Methods：The expression level of SOX7 mRNA in 7 hepatocarcinoma cell lines（HepG2,SNU449,SNU182,SMMC-7721,HUH-7,PLC-PRF-5 and Hep3B）,40 cases of HCC and the matched adjacent normal hepatic tissue was detected using Real-time PCR assay.Results：The expression level of SOX7 mRNA in 7 HCC cell lines was low.The expression level of SOX7 mRNA was （1.189±1.213）in HCC tissue,significantly lower than （1.821±1.718） in the normal tissue（t=2.040,P=0.048）.The SOX7 mRNA expression level was associated with the clinical stage（Z=2.158,P=0.031） of HCC patients.Conclusion：Down-regulation of SOX7 expression may be involved in carcinogenesis and development of HCC.