中文摘要：

目的探讨北京万寿路社区老年人群载脂蛋白E（apoE）基因多态性与老年外周动脉硬化闭塞病（peripheral arterial occlusive disease。PAOD）的相关性。方法用多重四引物扩增受阻突变体系PCR技术，检测了153例老年PAOD患者（PAOD组）及246例健康老年人（NC组）的apoE基因多态性。结果apoE等位基因呈多态性。apoE6种基因型频率（ε4/4，ε4／3，ε4／2，ε3/3，ε3／2，ε2/2）及3种等位基因频率（ε4，ε3，ε2）的分布在老年PAOD组与NC组间无显著差异（P〉0．05）。结论apoE基因多态性不是老年PAOD的独立危险因素。

英文摘要：

Objective To explore the relationship between apoE gene polymorphism and the susceptibility to peripheral arterial occlusive disease（PAOD） in the elderly of Beijing community. Methods Multiplex tetra-primer amplification refractory mutation system polymerase chain reac- tion（multiplex T-ARMS PCR） was used to detect apoE gene polymorphism in 246 control subjects（the normal control group,NC） and 153 PAOD patients（the PAOD group）. Results There were no obvious differences in the allele frequencies of apoE polymorphism between the PAOD and the NC groups. Conclusion ApoE polymorphism may not be associated with the risk of PAOD in the elderly of Beijing community.